Low-Density Parity-Check Coded High-order Modulation Schemes

In this thesis, we investigate how to support reliable data transmissions at high speeds in future communication systems, such as 5G/6G, WiFi, satellite, and optical communications. One of the most fundamental problems in these communication systems is how to reliably transmit information with a limited number of resources, such as power and spectral. To obtain high spectral efficiency, we use coded modulation (CM), such as bit-interleaved coded modulation (BICM) and delayed BICM (DBICM). To be specific, BICM is a pragmatic implementation of CM which has been largely adopted in both industry and academia. While BICM approaches CM capacity at high rates, the capacity gap between BICM and CM is still noticeable at lower code rates. To tackle this problem, DBICM, as a variation of BICM, introduces a delay module to create a dependency between multiple codewords, which enables us to exploit extrinsic information from the decoded delayed sub-blocks to improve the detection of the undelayed sub-blocks. Recent work shows that DBICM improves capacity over BICM. In addition, BICM and DBICM schemes protect each bit-channel differently, which is often referred to as the unequal error protection (UEP) property. Therefore, bit mapping designs are important for constructing pragmatic BICM and DBICM. To provide reliable communication, we have jointly designed bit mappings in DBICM and irregular low-density parity-check (LDPC) codes. For practical considerations, spatially coupled LDPC (SC-LDPC) codes have been considered as well. Specifically, we have investigated the joint design of the multi-chain SC-LDPC and the BICM bit mapper. In addition, the design of SC-LDPC codes with improved decoding threshold performance and reduced rate loss has been investigated in this thesis as well. The main body of this thesis consists of three parts. In the first part, considering Gray-labeled square M-ary quadrature amplitude modulation (QAM) constellations, we investigate the optimal delay scheme with the largest spectrum efficiency of DBICM for a fixed maximum number of delayed time slots and a given signal-to-noise ratio. Furthermore, we jointly optimize degree distributions and channel assignments of LDPC codes using protograph-based extrinsic information transfer charts. In addition, we proposed a constrained progressive edge growth-like algorithm to jointly construct LDPC codes and bit mappings for DBICM, taking the capacity of each bit-channel into account. Simulation results demonstrate that the designed LDPC-coded DBICM systems significantly outperform LDPC-coded BICM systems. In the second part, we proposed a windowed decoding algorithm for DBICM, which uses the extrinsic information of both the decoded delayed and undelayed sub-blocks, to improve the detection for all sub-blocks. We show that the proposed windowed decoding significantly outperforms the original decoding, demonstrating the effectiveness of the proposed decoding algorithm. In the third part, we apply multi-chain SC-LDPC to BICM. We investigate various connections for multi-chain SC-LDPC codes and bit mapping designs and analyze the performance of the multi-chain SC-LDPC codes over the equivalent binary erasure channels via density evolution. Numerical results demonstrate the superiority of the proposed design over existing connected-chain ensembles and over single-chain ensembles with the existing bit mapping design

Highly Prevalent Multidrug-Resistant Salmonella From Chicken and Pork Meat at Retail Markets in Guangdong, China

This study aimed to investigate the prevalence, serotype distribution, and antibiotic resistance, and to characterize the extended spectrum β-lactamases (ESBLs) producing Salmonella isolates from chicken and pork meats from retail markets in Guangdong province, China. A total of 903 retail meat samples (475 chicken and 428 pork meats) were obtained from six cities (Guangzhou, Shenzhen, Heyuan, Shaoguan, Foshan, and Yunfu) of Guangdong province between May 2016 and April 2017. High levels of Salmonella contamination were detected in chicken (302/475, 63.6%) and pork (313/428, 73.1%). Thirty-eight serotypes were identified in 615 detected Salmonella, and the serotypes varied greatly between chicken and pork samples. Agona (55/302, 18.2%), Corvallis (45/302, 14.9%), Kentucky (38/302, 12.6%), Mbandaka (32/302, 10.6%) was the dominant serotypes in chicken samples. However, Typhimurium (78/313, 24.9%), Rissen (67/313, 24.1%), Derby (66/313, 21.1%), and London (48, 15.3%) were the most common in pork samples. High rates of antibiotic resistance were found to sulfisoxazole (468/615, 76.1%), tetracycline (463/615, 75.3%), ampicillin (295/615, 48.0%), and ofloxacin (275/615, 44.7%). Notably, antimicrobial susceptibility tests identified resistance to polymyxin B (12/615, 2.0%) and imipenem (3/615, 0.5%). Multidrug-resistance (MDR) was detected in Salmonella isolated from chicken (245/302, 81.1%) and pork (229/313, 73.2%). The resistance rate of different Salmonella serotypes varied widely. Especially, isolates such as Typhimurium, Agona, Corvallis and Kentucky exhibited highly resistance to antibiotics. The MDR rate of Salmonella isolates from chicken was significantly higher than that from pork isolates (P < 0.05). Twenty-one Salmonella isolates were identified as ESBLs-producing, covering six Salmonella serotypes and displaying different pulse field gel electrophoresis (PFGE) genotypes. BlaOXA-1 was the dominant ESBLs gene (9/21, 42.9%), followed by blaCTX-M-55 (5/21, 23.8%). This study indicated that Salmonella was widespread in chicken and pork from retail markets in Guangdong province and the isolates showed high multidrug-resistance, especially the known multidrug-resistant Salmonella serotypes. Therefore, it is important to focus on Salmonella serotypes and strengthen the long-term monitoring of MDR Salmonella serotypes in animal-derived foods

Assessing the Customers' Risk in using Bank Card Business

The development of bank card business has severely challenged the improvement of risk-controlling technology. While assessing risk is the foundation of risk-controlling in bank card business. Presently, domestic banks have set up their customer data base. By analyzing the status of risk assessing in risk-controlling, this article tries to applying Fisher Discrimination Approach to assessing customers' risk and overcomes the difficulty of determining the influential factors' share in traditional bank assessing approach

Immune Response of A Novel ATR-AP205-001 Conjugate Anti-hypertensive Vaccine

Abstract We developed a virus-like particle (VLP)-based therapeutic vaccine against angiotensin II receptor type 1, ATR-AP205-001, which could significantly reduce the blood pressure and protect target organs of hypertensive animals. In this study, we focused on the immunological effect and safety of the VLP-based vaccine. By comparing to the depolymerized dimeric vaccine ATR-Dimer-001, we found that ATR-AP205-001 reached subcapsular sinus of lymph node shortly after administration, followed by accumulation on follicle dendritic cells via follicle B cell transportation, while ATR-Dimer-001 vaccine showed no association with FDCs. ATR-AP205-001 vaccine strongly activated dendritic cells, which promoted T cells differentiation to follicular helper T cells. ATR-AP205-001 vaccine induced powerful germinal center reaction, which was translated to a boost of specific antibody production and long-lasting B cell memory, far superior to ATR-Dimer-001 vaccine. Moreover, neither cytotoxic T cells, nor Th1/Th17 cell-mediated inflammation was observed in ATR-AP205-001 vaccine, similar to ATR-Dimer-001 vaccine. We concluded that ATR-AP205-001 vaccine quickly induced potent humoral immunity through collaboration of B cells, follicular dendritic cells and follicular helper T cells, providing an effective and safe intervention for hypertension in the future clinical application